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Micellization behavior of temperature-responsive poly (N-isopropylacrylamide) grafted dextran copolymers

โœ Scribed by Li-Qun Wang; Kehua Tu; Yuping Li; Jun Fu; Fusheng Yu

Book ID
110391750
Publisher
Springer
Year
2002
Tongue
English
Weight
324 KB
Volume
21
Category
Article
ISSN
0261-8028

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Poly (N-isopropylacrylamide) (PNIPAAm) was grafted to dextran using ceric ion as redox initiator. The graft copolymers formed temperature responsive materials and can be used to construct polymeric micelles as drug carriers for colon-site 1 1 3 specifically delivery. The chemical structure of the gr

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## Abstract Poly(__N__โ€isopropylacrylamide) (PNIPAAm) grafted dextran nanogels with dodecyl and thiol end groups have been synthesized by RAFT process. Dodecylโ€terminated polymers (DexPNI) can be readily dissolved in water and further self assemble into ordered stable nanostructures through direct

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## Abstract **Summary:** RAFT polymerization was used to prepare PMMAโ€__b__โ€PNIPAM copolymers. Two different chain transfer agents, tBDB and MCPDB, were used to mediate the sequential polymerizations. Micellar solutions and gels were prepared from the resulting copolymers in aqueous solution. When