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MHC–peptide specificity and T-cell epitope mapping: where immunotherapy starts

✍ Scribed by Maurizio Provenzano; Monica C. Panelli; Simone Mocellin; Laura Bracci; Giovanni Sais; David F. Stroncek; Giulio C. Spagnoli; Francesco M. Marincola

Book ID
116758052
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
426 KB
Volume
12
Category
Article
ISSN
1471-4914

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## Abstract The advent in recent years of the application of tetrameric arrays of class I peptide–MHC complexes now enables us to detect and study rare populations of antigen‐specific CD8+ T cells. However, available methods cannot visualize or determine the number and distribution of these TCR lig