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Degenerate recognition of T cell epitopes: impact of T cell receptor reserve and stability of peptide:MHC complexes

✍ Scribed by Mandy L Ford; Brian D Evavold


Book ID
116755251
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
145 KB
Volume
40
Category
Article
ISSN
0161-5890

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Antigen-specific T-cell activation requires the formation of a transient cell-cell conjugate between a T cell and an appropriate antigen presenting cell (APC). Focal aggregation of T-cell receptor (TCR) molecules at the T-cell-APC membrane interface accompanies formation of multiple non-covalent int