Non-MHC-linked genes in autoimmune disea
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Henri-Jean Garchon
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Article
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1992
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Elsevier Science
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English
β 886 KB
The gene responsible for the lpr mutation in MRL mice that are prone to systemic lupus erythematosus has been shown to encode the apoptosis-inducing Fas antigen, thus pointing to control of apoptosis as a major regulatory mechanism in autoimmunity. In the non-obese diabetic mouse model for insulin-d