✦ LIBER ✦

MHC class I and class II structures

✍ Scribed by E Yvonne Jones

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 441 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80162-8

No coin nor oath required. For personal study only.

✦ Synopsis

The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides. Recent MHC class II structures have illustrated the mode of peptide binding both in mature complexes and in the MHC class II complex with a fragment of invariant chain (CLIP) during maturation.

📜 SIMILAR VOLUMES

MHC class II molecular structure — permi

MHC class II molecular structure — permitted pairs?

✍ R.I. Lechler 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 423 KB

Structural compartmentalization of MHC c

Structural compartmentalization of MHC class II signaling function

✍ William F. Wade; Jean Davoust; Jean Salamero; Pascale André; Tania H. Watts; Joh 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 690 KB

Techniques used to define human MHC anti

Techniques used to define human MHC antigens: monoclonals, class I and class II biochemistry

✍ J.S.S. Lanchbury 📂 Article 📅 1991 🏛 Elsevier Science 🌐 English ⚖ 434 KB

Shared regulatory elements in the promot

Shared regulatory elements in the promoters of MHC class I and class II genes

✍ Peter J van den Elsen; Ad Peijnenburg; Marja C.J.A van Eggermond; Sam J.P Gobin 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 432 KB

ranscription of major histocompatibility complex (MHC) class II genes is controlled by a number of transcription factors that interact with a set of conserved cisacting regulatory elements within the promoter region of MHC class II genes. These regulatory sequences include the W/S, X1, X2 and Y-box

MHC class I-like, class II-like and CD1

MHC class I-like, class II-like and CD1 molecules: distinct roles in immunity

✍ Evan M. Beckman; Michael B. Brenner 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 769 KB

Endosomal proteolysis and MHC class II f

Endosomal proteolysis and MHC class II function

✍ Harold A Chapman 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 962 KB

Newly synthesized MHC class II (x and 13 chains associate with a protein chaperone, the invariant chain, which promotes the proper assembly of MHC class II complexes and their trafficking through cells and prevents their untimely loading with peptides. Efficient loading of MHC class II heterodimers