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MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

✍ Scribed by Bonfils, C.; Hou, Y.; Yan, P. T.; Trachy-Bourget, M.-C.; Kalita, A.; Liu, J.; Lu, A.-H.; Zhou, N. Z.; Robert, M.-F.; Fournel, M.


Book ID
111931298
Publisher
American Association for Cancer Research
Year
2008
Tongue
English
Weight
617 KB
Volume
7
Category
Article
ISSN
1535-7163

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## Abstract AN‐7, a prodrug of butyric acid, induced histone hyperacetylation and differentiation and inhibited proliferation of human prostate 22Rv1 cancer cells __in vitro__ and __in vivo.__ In nude mice implanted with these cells, 50 mg/kg AN‐7 given orally thrice a week led to inhibition of tum