๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

โœ Scribed by Shiro Akinaga; Kayo Nomura; Katsushige Gomi; Masami Okabe


Publisher
Springer
Year
1993
Tongue
English
Weight
728 KB
Volume
32
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


A derivative of staurosporine (CGP 41 25
โœ Thomas Meyer; Urs Regenass; Doriano Fabbro; Enrica Alteri; Johannes Rรถusel; Marc ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 632 KB

Analogues of staurosporine were synthesized and their ability to inhibit protein kinases was examined. Staurosporine is a potent but non-selective inhibitor of in vitro protein kinase C (PKC) activity (K5, 6.0 nn). The derivative CGP 41 25 I had reduced PKC activity with an IC,, of 50 nn but showed

Activation of Protein Kinase C in Vitro
โœ P.J. Robinson; J.P. Liu; W. Chen; T. Wenzel ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 728 KB

MARCKS is a widespread cellular phosphoprotein that migrates at \(80-87 \mathrm{kDa}\) on polyacrylamide gels. It is phosphorylated apparently exclusively by protein kinase C (PKC) and its phosphorylation in intact cells can be used as an index of intracellular PKC activation. Most methods for the d

Antitumor activity of the selective epid
โœ Ichiro Naruse; Tohru Ohmori; Yoko Ao; Hisao Fukumoto; Toshio Kuroki; Masatomo Mo ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 216 KB ๐Ÿ‘ 1 views

## Abstract Selective tyrosine kinase inhibitors are regarded as promising antitumor agents for cancer treatment. Iressaยฎ (ZD1839) is an orally active, selective EGFRโ€TKI (epidermal growth factor receptorโ€tyrosine kinase inhibitor) that blocks signal transduction pathways implicated in cancer cell