Metronidazole–Deoxybenzoin Derivatives as Anti-Helicobacter pylori Agents with Potent Inhibitory Activity against HPE-Induced Interleukin-8

✍ Scribed by Yin Luo; Huan-Qiu Li; Yang Zhou; Zi-Lin Li; Tao Yan; Hai-Liang Zhu

• Book ID: 102105333
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 273 KB
• Volume: 5
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.201000126

✦ Synopsis

Abstract

A series of new metronidazole–deoxybenzoin derivatives were synthesized and evaluated for their antimicrobial activity against Helicobacter pylori__. Highly selective anti‐__H. pylori activity was also observed in synthesized compounds. Compound 34 exhibited the most potent activity, similar to the positive control amoxicillin. Furthermore, compounds 17 and 34 were able to significantly decrease H. pylori water extract (HPE)‐induced production of interleukin‐8 (IL‐8) in gastric mucosal cells, which did not show any effect on the cell viability.