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Methylxanthine-facilitated shock-induced aggression in the rat

โœ Scribed by Burr Eichelman; Elaine Orenberg; Pamela Hackley; Jack Barchas

Book ID
104772012
Publisher
Springer
Year
1978
Tongue
English
Weight
349 KB
Volume
56
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

The methylxanthines caffeine and aminophylline, in daily doses of 100 mg/kg, facilitated shock-induced aggression in the rat. Under the limited parameters of this study, there was no induction of mouse-killing behavior or alteration of jump thresholds. Additional studies showed the optimal dose and time course for the facilitation of shock-induced aggression by caffeine to be 50 mg/kg administered i.p. 4 h prior to testing. Facilitation of a central adrenergic system may be the mechanism of action.

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