Kidney toxicity of 3-methylxanthine in the rat

✍ Scribed by R. Sellman; P. J. Klemi

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 441 KB
• Volume: 4
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550040605

✦ Synopsis

The effects of 3-methylxanthme, the pharmacologically active metabolite of theophylline, on the kidneys of Wistar rats after short-term administration were studied. 3-Methylxanthine was administered in oral doses of 0 (control), 50, 100 and 200 mg per kg per day for 1,8 and 16 days. The kidneys were examined by light and electron microscopy. Tubular necrosis was noticed at a dose level of 100 mg kg-' after 16 days and at a dose level of 200 mg lcg-' after 8 days. Elevated values of serum urea were found after 1 day of treatment with a dose of 200 mg kg-' and after 16 days with a dose of 100 mg kg-'. Elevated values of serum creatinine were detected after 8 days of treatment with a dose of 200 mg kg-'. The results indicate dose-and time-related renal failure following administration of 3-methylxanthine.