Methylation status of the fragile histidine triad and E-cadherin genes in plasma of cervical cancer patients
โ Scribed by C.C. REN; X.H. MIAO; B. YANG; L. ZHAO; R. SUN; W.Q. SONG
- Book ID
- 109085883
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 117 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1048-891X
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The fragile histidine triad (FHIT) gene plays an important role in anti-cancer and the abnormal methylation of FHIT gene is found in many carcinomas. The epigenetic changes of tumor suppressor genes (TSG) are now recognized as an abnormal mechanism contributing to the development of myelodysplastic
## BACKGROUND. Human papillomaviruses (HPV) are the most important etiologic factor for cervical carcinoma. However, additional cellular events may be necessary for malignant progression in the cervix. Recently, the fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, was