Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomeraseassociated protein (TP1) and human telomerase catalytic subunit (hTERT), have
β¦ LIBER β¦
Methylation profile in benign, borderline and malignant ovarian tumors
β Scribed by K. F. Tam; V. W. S. Liu; S. S. Liu; P. C. K. Tsang; A. N. Y. Cheung; A. M. W. Yip; H. Y. S. Ngan
- Book ID
- 106123652
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 601 KB
- Volume
- 133
- Category
- Article
- ISSN
- 1432-1335
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## Abstract ## BACKGROUND. Methylationβmediated suppression of detoxification, DNA repair, and tumor suppressor genes has been implicated in cancer development and progression. Studies also have indicated that concordant methylation of multiple genes (methylator phenotypes), rather than a single g