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Methylation Patterns of the Human β-Glucuronidase Gene Locus: Boundaries of Methylation and General Implications for Frequent Point Mutations at CpG Dinucleotides

✍ Scribed by Shunji Tomatsu; Koji O Orii; M.Rafiqul Islam; Gul N Shah; Jeffrey H Grubb; Kazuko Sukegawa; Yasuyuki Suzuki; Tadao Orii; Naomi Kondo; William S Sly

Book ID: 115615563
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 524 KB
Volume: 79
Category: Article
ISSN: 0888-7543
DOI: 10.1006/geno.2002.6706

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## Communicated by Nobuyoshi Shimizu The methylation pattern at CpG sites of a housekeeping gene correlates with the likelihood of mutation. Mucopolysaccharidosis (MPS) type II, an X-linked disorder, results from the deficiency of iduronate-2-sulfatase (IDS). In these patients, over 35% of indepen