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Methylation patterns of entire human β-glucuronidase gene locus: boundaries of methylation and general implications for frequent point mutations at CpG dinucleotides

✍ Scribed by S Tomatsu; K Orii; WS Sly


Book ID
114813375
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
175 KB
Volume
91
Category
Article
ISSN
0803-5253

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## Communicated by Nobuyoshi Shimizu The methylation pattern at CpG sites of a housekeeping gene correlates with the likelihood of mutation. Mucopolysaccharidosis (MPS) type II, an X-linked disorder, results from the deficiency of iduronate-2-sulfatase (IDS). In these patients, over 35% of indepen