Methylation of the alpha-fetoprotein gene in isogenic rat hepatoma and liver cell lines
β Scribed by Keiko Sakuma; Jeffry R. Cook; Catharine L. Smith; Jen-Fu Chiu
- Book ID
- 115760811
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 776 KB
- Volume
- 143
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
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## Abstract Cell clones producing low amounts of alphaβfetoprotein were isolated from AH66 cell line from an ascites hepatoma producing high amounts of AFP __in vitro__. The growth rate and the chromosome constitution were compared between clones producing high and low amounts of AFP. No significan
A daunorubicin (DNR)-resistant variant (AH66DR) of alpha-fetoprotein (AFP)-producing rat ascites hepatoma AH66 was established. AH66DR was 169 times more resistant to DNR than AH66. A growth-inhibitory effect due to the decrease in sugar uptake following treatment of the cell lines with specific ant