Methylation of Repetitive DNA Sequences and Differentiation of Friend Erythroleukemia Cells
โ Scribed by NATALIE SCHNEIDERMAN; ZEE-FEN CHANG; JUDITH K. CHRISTMAN
- Book ID
- 119862856
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 115 KB
- Volume
- 567
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Friend erythroleukemia cells (FELC) served as a model system for cell differentiation because these cells can be triggered to differentiate by a variety of chemical agents. Treatment with the classical inducer of differentiation, hexamethylene bisacetamide (HMBA), stimulated superoxide dismutase (SO
Dimethylsulfoxide (DMSO) converts almost all of the undifferentiated murine erythroleukemia cells (MEL or Friend cells, clone 745A) in a culture to differentiated cells that contain high levels of hemoglobin and that stop growing after a limited number of cell divisions. Contrary to other reports-th