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Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism

✍ Scribed by Verheij, H. M.; Volwerk, J. J.; Jansen, E. H. J. M.; Puyk, W. C.; Dijkstra, B. W.; Drenth, J.; De Haas, G. H.


Book ID
121466375
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
997 KB
Volume
19
Category
Article
ISSN
0006-2960

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Role of histidine-50, glutamic acid-96,
✍ Javier Lacadena; Álvaro MartΓ­nez del Pozo; Antonio MartΓ­nez-Ruiz; JosΓ© Manuel PΓ© πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 424 KB

␣-Sarcin is a ribotoxin secreted by the mold Aspergillus giganteus that degrades the ribosomal RNA by acting as a cyclizing ribonuclease. Three residues potentially involved in the mechanism of catalysis-histidine-50, glutamic acid-96, and histidine-137-were changed to glutamine. Three different sin