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Methyl deficiency, DNA methylation, and cancer: Studies on the reversibility of the effects of a lipotrope-deficient diet

โœ Scribed by Judith K. Christman; Mei-Ling Chen; Gholamreza Sheikhnejad; Mark Dizik; Susana Abileah; Elsie Wainfan


Book ID
108033106
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
868 KB
Volume
4
Category
Article
ISSN
0955-2863

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Young rats were maintained in a 10% oxygen atmosphere for 2 , 6 , and 10 days and administered normal rat chow and water ad libitum. Thereafter, their hepatic S-adenosyl-L-methionine (AdoMet) and activity and mRNA levels of AdoMet synthetase were assayed. AdoMet levels decreased by 45% after 10 days