Methyl benzylpenillonate: a penicillin rearrangement product
โ Scribed by Clegg, W.
- Book ID
- 114525607
- Publisher
- International Union of Crystallography
- Year
- 1978
- Weight
- 298 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0567-7408
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๐ SIMILAR VOLUMES
The acid catalyzed ring expansion (1) of penicillin sulfoxide esters, 1, to deacetoxy cephalosporins, 2, has assumed added importance due to the demonstrated oral effectiveness of the broad-spectrum antibiotic, cephalexin (2). We now wish to report additional studies that further aid in elucidating
Abstraef. Treatmem of 7-triethylsilyl-13-oxobaccatin III (1) with sodium hydride and methyl iodide gave the methylated ten-membered rin~ compound 2 that rearranged, via intramolecular aldol eundensation, to unsaturated decalin ring system (3, 4,5 ). These molecules were characterized by ID