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Methotrexate-vindesine association in the treatment of head and neck cancer Influence of vindesine on methotrexate's pharmacokinetic behavior

✍ Scribed by N. Lena; A. M. Imbert; T. Pignon; R. Favre; G. Meyer; J. P. Cano; Y. Carcassonne


Book ID
104684897
Publisher
Springer
Year
1984
Tongue
English
Weight
360 KB
Volume
12
Category
Article
ISSN
0344-5704

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Methotrexate-vindesine association in he
✍ P. Bore; N. Lena; A. M. Imbert; R. Favre; J. P. Cano; G. Meyer; Y. Carcassonne πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 453 KB

High-dose methotrexate (HD-MTX) infusions associated with vindesine (VDS) have been used in the treatment of head and neck cancer. In a previous study, VDS was shown to increase the apparent plasma clearance of MTX. We have studied the MTX hydroxylation process in the presence of VDS. Different rout