Methotrexate-vindesine association in he
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P. Bore; N. Lena; A. M. Imbert; R. Favre; J. P. Cano; G. Meyer; Y. Carcassonne
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Article
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1986
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Springer
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English
β 453 KB
High-dose methotrexate (HD-MTX) infusions associated with vindesine (VDS) have been used in the treatment of head and neck cancer. In a previous study, VDS was shown to increase the apparent plasma clearance of MTX. We have studied the MTX hydroxylation process in the presence of VDS. Different rout