Interim report on a phase III study of bleomycin and methotrexate with radiotherapy in the treatment of inoperable head and neck cancer
β Scribed by Theodore L. Phillips; Ivan J. Silverberg; Karen K. Fu; Michael A. Friedman; Frank Torti; Marsha Kohler; Stephen K. Carter
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 89 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0360-3016
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Background. Patients with advanced, inoperable head and neck cancers have cure rates of approximately 10-15%. In these patients, concomitant chemoradiotherapy seems to improve local control and survival. 5-Fluorouracil(5-FU) administered by continuous infusion and cisplatin plus concomitant conventi
Thirty patients with recurrent and/or metastatic head and neck cancer were treated with sequentially administered methotrexate (MTX) and piritrexim (PTX). The treatment schedule consisted of intravenous (IV) MTX (50 mg/m') administered on day 1 and oral PTX (75 mg/mz) administered twice daily on day