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Methotrexate-mediated inhibition of RAD51 expression and homologous recombination in cancer cells

✍ Scribed by Li-Qing Du; Xiao-Qing Du; Jian-Qiang Bai; Yan Wang; Qing-Shan Yang; Xiao-Chun Wang; Peng Zhao; Hong Wang; Qiang Liu; Fei-Yue Fan

Book ID
113043116
Publisher
Springer-Verlag
Year
2012
Tongue
English
Weight
367 KB
Volume
138
Category
Article
ISSN
1432-1335

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## Abstract In medulloblastomas, which are highly malignant cerebellar tumors of the childhood genotoxic treatments such as cisplatin or γ‐irradiation are frequently associated with DNA damage, which often associates with unfaithful DNA repair, selection of new adaptations and possibly tumor recurr