Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia
โ Scribed by Bhojwani, D.; Sabin, N. D.; Pei, D.; Yang, J. J.; Khan, R. B.; Panetta, J. C.; Krull, K. R.; Inaba, H.; Rubnitz, J. E.; Metzger, M. L.; Howard, S. C.; Ribeiro, R. C.; Cheng, C.; Reddick, W. E.; Jeha, S.; Sandlund, J. T.; Evans, W. E.; Pui, C.-H.; Relling, M. V.
- Book ID
- 121859111
- Publisher
- American Society of Clinical Oncology
- Year
- 2014
- Tongue
- English
- Weight
- 187 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0732-183X
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Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3
One hundred fifty-three children with ALL were diagnosed in Norway in the period August 1975-December 1980. One hundred ond remission. thirty-two of them received 3 infusions of methotrexate as consolidation therapy combined with methotrexate intrathecally as CNS prophylaxis. Eleven (44%) of the tot