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Methotrexate hepatotoxic effects in children with juvenile rheumatoid arthritis

✍ Scribed by Alberto Martini; Angelo Ravelli; Stefania Viola; Roberto G. Burgio

Book ID
117162501
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
210 KB
Volume
119
Category
Article
ISSN
1097-6833

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Children with juvenile rheumatoid arthritis (JRA) have been reported to require higher doses (per kg body weight) of methotrexate (MTX) than adults with rheumatoid arthritis to control their disease. The purpose of the present study was to characterise the plasma pharmacokinetics of MTX and its majo

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## To assess the effects of methotrexate (MTX) therapy on radiologic progression in juvenile rheumatoid arthritis (JRA). Methods. We evaluated serial wrist radiographs for carpal length in 23 JRA patients with bilateral wrist involvement, before and during MTX treatment. These carpal length measur