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Methotrexate concentrations in synovial membrane and trabecular and cortical bone in rheumatoid arthritis patients

✍ Scribed by Christophe Bologna; Leila Edno; Juan-Manuel Anaya; Francois Canovas; Marc Vanden Berghe; Christian Jorgensen; Marc Galtier; Bernard Combe; Francoise Bressolle; Jacques Sany

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 417 KB
Volume: 37
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780371210

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To determine methotrexate (MTX) concentrations in the synovial membrane (SM) and cortical and trabecular bone of rheumatoid arthritis (RA) patients. Methods. Ten RA patients (9 women, 1 man; mean +. SD age 49.2 f 10.6, mean disease duration 13.2 f 9.9 years) undergoing surgical procedures for rheumatoid articular lesions participated in this study. Mean +. SD MTX treatment duration was 26.4 f 21.3 months. The day preceding surgery, 10 mg of MTX was administered intramuscularly. During surgery, a mean & SD of 19.7 f 2.6 hours after MTX administration, SM, bone fragments, and blood were collected simultaneously. MTX was assayed by fluorescence polarization immunoassay in plasma and tissues. Results. The mean f SD plasma concentration was 0.0252 +-0.01 nmoles/ml at the time of tissue sampling. The mean MTX concentration in SM was 0.285 & 0.159 nmoledgm. The mean MTX concentrations in trabecular and cortical bone were 0.292 f 0.164 and 0.286 f 0.126 nmoledgm, respectively. Conclusion. After intramuscular administration, high MTX concentrations are found in SM and cortical and trabecular bone of RA patients.

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