Aspirin alters methotrexate disposition in rheumatoid arthritis patients
β Scribed by Clinton F. Stewart; Ronald A. Fleming; Bernard F. Germain; Mitchel J. Seleznick; William E. Evans
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 679 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Methotrexate (MTX) is effective in the treatment of refractory rheumatoid arthritis (RA). Its use by practitioners has become commonplace, even though it is not yet approved by the Food and Drug Administration for this use. One might assume, therefore, that there is a general understanding, among pr
## Abstract ## Objective There is evidence supporting a therapeutic range for methotrexate polyglutamate (MTXGlu) concentrations in the treatment of rheumatoid arthritis (RA). Knowledge of the pharmacokinetics of MTXGlu~1β5~ is required for optimal timing of blood sampling. The aim of this study w