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Methods of DNA adduct determination and their application to testing compounds for genotoxicity

โœ Scribed by D. H. Phillips; P. B. Farmer; F. A. Beland; R. G. Nath; M. C. Poirier; M. V. Reddy; K. W. Turteltaub


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
91 KB
Volume
35
Category
Article
ISSN
0893-6692

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Iron present in biological samples prevents the extraction of DNA by hot acid hydrolysis as used in both the Schneider and Ogur-Rosen procedures [Schneider, W. C. (1945) J. Biol. Chem. 161,293-303; Ogur, M., and Rosen, G. (1950)Arch. Biochem. 25,262-276.1 for DNA determination. Purified DNA, which