Methods for the Synthesis of 3,4-2H-Dihydropyrroles (Δ1-Pyrrolines) and Their Chemical Transformations. (Review)
✍ Scribed by M.-G. A. Shvekhgeimer
- Book ID
- 111544796
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 332 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0009-3122
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📜 SIMILAR VOLUMES
New derivatives of 3,4-dihydrospiro[cycloalkane- \(1^{\prime}, 2(1 H)\)-quinolines] were obtained from cycloheptanone and cyclooctanone via facile three steps hetero spiro annulation process. Their nitro derivatives were prepared through electrophilic substitution reactions.
N-t-Butylacetamidines 1 on heating with methyl acrylate (2) at 200˚ gave the 4,5-dihydro-3H-pyridin-2one derivatives 5. Michael addition of the acetamidines 1 as their ene-1,1-diamine tautomers 1' to 2 and the subsequent cyclization of the adducts gave derivatives 5. Amidines 1 on reaction with trim