Methods for controlling the regioselection in the reaction of 3-amino-5-benzylthio-1,2,4-triazole with acetylacetaldehyde dimethyl acetal
✍ Scribed by William T. Monte; William A. Kleschick; Richard W. Meikle; Sigrid W. Snider; Jon Bordner
- Book ID
- 112129385
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1989
- Tongue
- English
- Weight
- 230 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-152X
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## Abstract magnified image The three‐component condensation of 3‐amino‐5‐alkylthio‐1,2,4‐triazoles with aromatic aldehydes and β‐ketoester was studied to develop a regioselective Biginelli‐like reaction. The results indicated that the reaction solvent and the properties of the β‐ketoester compone
It is known [1, 2] that the reactions of binucleophiles with ketones containing the activated methyl or methylene group, or with the products of the self-condensation of these ketones, may lead to one and the same substance. We established that the boiling of the solutions of the 3-amino-l,2,4-triaz