Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better u
[Methods and Principles in Medicinal Chemistry] Drug-Membrane Interactions Volume 15 || Computer Simulation of Phospholipids and Drug-Phospholipid Interactions
β Scribed by Seydel, Joachim K.; Wiese, Michael
- Book ID
- 121716582
- Publisher
- Wiley
- Year
- 2002
- Weight
- 307 KB
- Volume
- 10.1002/3527600639
- Category
- Article
- ISBN-13
- 9783527600632
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The enormous cost incurred when a candidate drug fails in a clinical trial because of poor pharmacological parameters or severe side effects makes it imperative to screen for "safe" drugs in the very early stages of drug development. Various biochemical and other in vitro assays are thus used in con
The Lock-and-key Principle Formulated By Emil Fischer As Early As The End Of The 19th Century Has Still Not Lost Any Of Its Significance For The Life Sciences. The Basic Aspects Of Ligand-protein Interaction May Be Summarized Under The Term 'molecular Recognition' And Concern The Specificity As Well