✍ Scribed by Böhm, H.-J.; Schneider, G.
No coin nor oath required. For personal study only.
The Lock-and-key Principle Formulated By Emil Fischer As Early As The End Of The 19th Century Has Still Not Lost Any Of Its Significance For The Life Sciences. The Basic Aspects Of Ligand-protein Interaction May Be Summarized Under The Term 'molecular Recognition' And Concern The Specificity As Well As Stability Of Ligand Binding. Molecular Recognition Is Thus A Central Topic In The Development Of Active Substances, Since Stability And Specificity Determine Whether A Substance Can Be Used As A Drug. Nowadays, Computer-aided Prediction And Intelligent Molecular Design Make A Large Contribution. Protein-ligand Interactions From Molecular Recognition To Drug Design; Contents; Preface; A Personal Foreword; List Of Contributors; List Of Abbreviations; Prologue; 1 Prediction Of Non-bonded Interactions In Drug Design; 2 Introduction To Molecular Recognition Models; 3 Experimental Approaches To Determine The Thermodynamics Of Protein-ligand Interactions; 4 The Biophore Concept; 5 Receptor-ligand Interaction; 6 Hydrogen Bonds In Protein-ligand Complexes; 7 Principles Of Enzyme-inhibitor Design; 8 Tailoring Protein Scaffolds For Ligand Recognition. Edited By H.-j. Böhm And G. Schneider. Includes Bibliographical References And Index.
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