๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

โœ Scribed by Raj Badhan; Jeffrey Penny; Aleksandra Galetin; J. Brian Houston

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
527 KB
Volume
98
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Development of a novel probe for measuri
Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein
โœ Lawrence P. Cogswell III; Douglas E. Raines; Sonali Parekh; Oliver Jonas; John E ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 305 KB

A novel probe was developed to measure drug association with the F1\*S variant of the human serum protein alpha 1-acid glycoprotein (AGP). The molecule 2hydroxy-3,5-diiodo-N-[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenching its native ยฏuorescence. This quenching was ยฎtted to a two-site

In Vitro absorption and secretory quotie
In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates
โœ Victoria E. Thiel-Demby; Timothy K. Tippin; Joan E. Humphreys; Cosette J. Serabj ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 92 KB ๐Ÿ‘ 1 views

The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com

Studies on the Interactions between Drug
Studies on the Interactions between Drugs and Estrogen: Analytical Method for Prediction System of Gynecomastia Induced by Drugs on the Inhibitory Metabolism of Estradiol Using Escherichia coli Coexpressing Human CYP3A4 with Human NADPH-Cytochrome P450 Reductase
โœ Takashi Satoh; Ken-ichi Fujita; Haruka Munakata; Shinji Itoh; Katsunori Nakamura ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 94 KB

To establish a prediction system for drug-induced gynecomastia in clinical fields, a model reaction system was developed to explain numerically this side effect. The principle is based on the assumption that 50% inhibition concentration (IC 50 ) of drugs on the in vitro metabolism of estradiol (E2)