๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A pharmacokinetic model for the percutaneous absorption of indomethacin and the prediction of drug disposition kinetics

โœ Scribed by Taro Ogiso; Yoshimasa Ito; Masahiro Iwaki; Hidehiko Atago


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
497 KB
Volume
78
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Prediction of the disposition of midazol
โœ Sven Bjรถrkman; D. Russell Wada; Britt-Marie Berling; Gรถran Benoni ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB

The aim of this study was to predict the disposition of midazolam in individual surgical patients by physiologically based pharmacokinetic (PBPK) modeling and explore the causes of interindividual variability. Tissueยฑplasma partition coefยฎcients (k p ) were scaled from rat to human values by a physi

Dual sorption model for the nonlinear pe
โœ K. Kubota; E. Koyama; E. H. Twizell ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 414 KB

The nonlinear percutaneous permeation kinetics of timolol were studied in vitro with human cadaver skin. In the sorption isotherm (equilibrium) study, the plots of the amount of timolol per unit area of epidermis versus aqueous timolol concentration in equilibrium were curvilinear as the dual sorpti

Hepatobiliary disposition of valproic ac
โœ C L Booth; G M Pollack; K L Brouwer ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 271 KB

with phenobarbital-associated impairment of canalicu-Previous work in this laboratory has suggested that lar egress of some organic anions. This work further supthe nonlinear disposition of valproic acid (VPA) in the ports the utility of pharmacokinetic modeling in: (1) derat may be due to nonlinear

The kinetics of polyesterification. III.
โœ Chen Chong Lin; Ping Chang Yu ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 302 KB

A mathematical model for the apparent constants k l and k z which presents a quantitative explanation of the observed kinetic behavior in both uncatalyzed and acid-catalyzed polyesterification between ethylene glycol and a dibasic acid in different initial molar ratios was developed. This model cons

Evaluation of a chronically isolated int
โœ Fred G. J. Poelma; Josef J. Tukker ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 470 KB

A model is described to study absorption kinetics of drugs in the unanesthetized rat. The surgical technique consists of a long-term isolation of an intestinal segment inside the animal. This isolated loop is used in perfusion experiments. In this model the effects of anesthesia and surgical trauma