Methodological differences in correlating digoxin dissolution with bioavailability
โ Scribed by R. I. Poust; S. A. Fusari; D. Dittmar
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 209 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The cumulative urinary excretion of four different aspirin products (two tablets, a capsule, and a timed-release tablet) was determined in a crossover study using five subjects. Comparison of in vivo results showed a significant difference in cumulative urinary excretion levels at only 1 hr. The exc
tegrating disks. Milosovich (3) employed a tablet mounted in a die which was subjected to solvent agitation. The use of disks or tablets of pure drug with either method permits the determination of intrinsic dissolution rates as a function of temperature and agitation. Levy (4) has noted that a kno