✦ LIBER ✦
Development of in vitro dissolution tests which correlate quantitatively with dissolution rate-limited drug absorption in man
✍ Scribed by Gerhard Levy; Jack R. Leonards; Josephine A. Procknal
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 408 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
tegrating disks. Milosovich (3) employed a tablet mounted in a die which was subjected to solvent agitation. The use of disks or tablets of pure drug with either method permits the determination of intrinsic dissolution rates as a function of temperature and agitation.
Levy (4) has noted that a knowledge of intrinsic dissolution rate is not necessarily sufficient to determine the dissolution rate of a drug in paxticulate form. Frequently, certain complications arise that necessitate experimental measurement