✦ LIBER ✦

Methodological aspects of the determination of the acute inhalation toxicity of spray-can ingredients

✍ Scribed by J. Pauluhn; L. Machemer; G. Kimmerle; A. Eben

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 571 KB
Volume: 8
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550080608

No coin nor oath required. For personal study only.

✦ Synopsis

Spray-can ingredients, if liberated in confined spaces, are potential health hazards for man. Thus, appropriate inhalation toxicity studies have to be performed in accordance with internationally recognized guidelines, e.g. the US Environmental Protection Agency: Federal Insecticide, Fungicide and Rodenticide Act (FIFRA no. 81-3) or OECD no. 403.

One of the essential requirements of such guidelines is that test animals (preferably rats) be exposed to a steady-state concentration in a dynamic inhalation chamber for at least 4 hours. This is not easy to achieve with vapours released from a pressurized spray-can.

The method described here makes it possible to expose experimental animals in an inhalation chamber to a steady-state concentration of intermittently released spray jets of constant doses per jet. Animal experiments and theoretical considerations (computer simulations) have shown that the method presented allows an up-todate determination of the acute inhalation toxicity of spray-can ingredients.

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