Estimation of acute oral toxicity in rates by determination of the approximate lethal dose rather than the LD50
✍ Scribed by Gerald L. Kennedy Jr.; Rayanne L. Ferenz; Bruce A. Burgess
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 271 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
✦ Synopsis
The approximate lethal dose (ALD) to rats following oral administration of nine chemicals was determined. The A L D (lowest dose at which death was produced) for each chemical was used to define the general order of toxicity as being either extremely, highly, moderately, slightly, or practically non-toxic. For each of the nine chemicals tested, the category indicated by the A L D was identical with the category determined in the more extensive LD,, studies. In this study, an average of 6.8 rats was needed to determine the A L D while an average of 56.3 rats was needed to determine the LD,,.