The major concept of fragile X pathogenesis postulates that the fragile site at band Xq27.3 [Ira(X)] represents the primary defect. The expression of Ira(X) is predicted to be an intrinsic property of the mutated chromosome and, hence, should not be suppressed by X inactivation in females or induced
β¦ LIBER β¦
Methionine metabolism and fragile X expression
β Scribed by Howard-Peebles, Patricia N. ;Opitz, John M. ;Reynolds, James F.
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 175 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
β¦ Synopsis
Study of the methionine-folate pathways leads to the expectation that depletion of methionine would lead to enhanced fra(X) expression -in vitro (Scott
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