In order to analyse how many structural genes are implicated in the specific steps of the biosynthesis of methionine in Sacch. cerevisiae, a hundred mutants were studied by complementation. 21 groups were defined named MET1 to MET25. Neither recombination between independent mutants of the same comp
β¦ LIBER β¦
Methionine biosynthesis in Saccharomyces cerevisiae
β Scribed by Masselot, Monique ;Surdin-Kerjan, Yolande
- Book ID
- 104692043
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 695 KB
- Volume
- 154
- Category
- Article
- ISSN
- 0026-8925
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β¦ Synopsis
In Saccharomyces cerevisiae, the products of eleven different genes are needed for a functional sulfate assimilation pathway. Only five enzymatic steps are known in this pathway. The study of the gene-enzyme relationships has shown that the enzymes catalysing two of these steps are probably heteropolymeric. Moreover, mutations in three unlinked genes lead to multiple enzymatic losses. Different hypotheses are made to account for these results.
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