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Methiodide of the GABA antagonist (+)-bicuculline is levorotatory

✍ Scribed by Miklós Simonyi; Gábor Blaskó; Julianna Kardos; Márton Kajtár

Book ID
102075611
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
186 KB
Volume
1
Category
Article
ISSN
0899-0042

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Bicuculline methiodide (BMI), a y-aminobutyrate (GABA) antagonist, is a powerful convulsant agent when injected into the cerebral ventricles, amygdala, hippocampus, thalamus, neocortex, and deep prepiriform cortex in rats. In contrast, bilateral microinjection of BMI into the rat striatum confers pr