Cyclophosphamide (CP) is an alkylating agent widely used in treating cancer and autoimmune disease. CP is classified as a pregnancy risk factor D drug and is teratogenic in animals, but population studies have not conclusively demonstrated teratogenicity in humans. Six isolated reports of prenatally
Methimazole embryopathy: Delineation of the phenotype
โ Scribed by Clementi, Maurizio; Di Gianantonio, Elena; Pelo, Elisabetta; Mammi, Isabella; Basile, Rosaria Teresa; Tenconi, Romano
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 22 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19990305)83:1<43::aid-ajmg8>3.0.co;2-c
No coin nor oath required. For personal study only.
โฆ Synopsis
We report on a further case of congenital anomalies in a child exposed to methimazole during the first trimester of pregnancy (from first to seventh gestational week), and define a specific malformation pattern related to prenatal methimazole exposure and consisting of choanal and esophageal atresia, scalp defects, minor facial anomalies and psychomotor delay.
๐ SIMILAR VOLUMES
The tricho-dento-osseous (TDO) syndrome demonstrates kinky curly hair, thin-pitted enamel, taurodontism, and thickening of cortical bone. The purpose of this investigation was to characterize the phenotypic variation of TDO in 3, previously unreported, kindreds and to examine possible candidates for
The molecular revolution has produced its own nomenclature. Some say that we should adopt molecular nomenclature to replace syndrome nomenclature; others maintain that we should keep syndrome nomenclature to keep learning hurdles to a minimum. Here, we adopt an integrated approach suggested by Biese
The study of the neurobehavioral consequences of mutations of FMR1, the gene responsible for fragile X syndrome (FraX), has been based largely on correlations between mutation patterns and cognitive profile. Following the characterization of FMRP, the FMR1 gene product, preliminary correlations betw
In pitch-perfect prose, Angle of Declination tells the story of Allison Hayes and her husband Mike Bowman, a Vietnam vet whom she loves deeply yet struggles to understand. Mike and Allison's future seems boundless in 1973, but when their wanderlust takes them deep into the Canadian wilderness, somet
deficiency embryopathy due to a disorder of embryonic vitamin K metabolism.