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Methanolysis of 2-Phenylfuro[3,4-d] pyrimidine-5,7-dione

โœ Scribed by Thomas J. Schuian


Book ID
112124107
Publisher
Journal of Heterocyclic Chemistry
Year
1977
Tongue
English
Weight
91 KB
Volume
14
Category
Article
ISSN
0022-152X

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๐Ÿ“œ SIMILAR VOLUMES


A convenient synthesis of pyrazolo[3,4-d
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## Abstract Pyrazoloโ€[3,4โ€__d__]pyrimidineโ€4,6โ€diones **5** and pyrazolo[4,3โ€__d__]pyrimidineโ€5,7โ€diones **7** were synthesized by Curtius rearrangement of pyrazolic monoโ€esters **2** and **3** followed by heteroโ€cyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.

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Novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d] pyrimidine-5,7-diones were successfully synthesized with moderate to good yields using a new synthetic approach. The structures of the regio-isomers in this series were determined by single crystal X-ray analysis and NMR spectra.