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Metformin Is an AMP Kinase-Dependent Growth Inhibitor for Breast Cancer Cells

✍ Scribed by Zakikhani, M.; Dowling, R.; Fantus, I. G.; Sonenberg, N.; Pollak, M.


Book ID
126962081
Publisher
American Association for Cancer Research
Year
2006
Tongue
English
Weight
329 KB
Volume
66
Category
Article
ISSN
0008-5472

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Background and Objectives: Receptor tyrosine kinase (RTK) activation is critical for growth factor-mediated cell proliferation. Blockade of RTK activation inhibits growth factor-induced cell proliferation. A panel of RTK inhibitors (tyrphostins) have been tested and compared for their antiproliferat