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Metathesis of silicon-containing olefins: IX. Synthesis of 1-(trimethylsilyl)-1-alkenes by olefin metathesis

โœ Scribed by Zenon Foltynowicz; Cezary Pietraszuk; Bogdan Marciniec


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
250 KB
Volume
7
Category
Article
ISSN
0268-2605

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โœ Scott B. Hoyt; Clare London; Min Park ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 318 KB

The 1-benzazepin-2-one ring system is an important structural feature of marketed drugs, clinical candidates, and other bioactive molecules. We have developed a new benzazepinone synthesis that employs ring-closing olefin metathesis as a key step. This route provides efficient access to substituted