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Metastatic papillary carcinoma of the thyroid: The significance of extranodal extension

✍ Scribed by James R. Spires; K. Thomas Robbins; Mario A. Luna; Dr. Robert M. Byers

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
387 KB
Volume
11
Category
Article
ISSN
1043-3074

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✦ Synopsis

A retrospective study of patients with papillary carcinoma of the thyroid was conducted at The University of Texas M. D. Anderson Cancer Center to determine the significance of cervical nodal metastases in which the cancer has extended beyond the capsule of the node. The survival of 25 patients with extracapsular invasion was compared to 63 controls. There was no statistically significant difference in regional recurrence, distant metastases, death from cancer, or recurrence-free survival between the two groups. Surgically resectable extrathyroid extension of tumor at the primary site and the clinical stage of cervical metastases also had no prognostic significance. The most important prognostic factors for differentiated thyroid carcinoma remain the age and sex of the patient, the histology of the cancer, and the presence of distant metastatic disease. HEAD & NECK 11:242-246,1989

T h e natural history of thyroid cancer is highly variable and is influenced by several factors. Papillary thyroid carcinoma in the young is an indolent disease, whereas its anaplastic counterpart is perhaps the most aggressive neoplasm Acknowledgment: We would like to thank Patricia Wolf and Cindi Timmerman for their help in the preparation of this manuscript.

From the Departments of Head and Neck Surgery (Drs. Spires, Robbins.

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