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Metanestin, a glycoprotein with metastasis-associated expression in transitional cell carcinoma of the urinary bladder

✍ Scribed by Masakazu Takemoto; Tsutomu Shirahama; Teruo Miyauchi; Tetsusi Matsusako; Norio Kaneda; Hisako Muramatsu; Masayuki Ozawa; Yoshitada Ohi; Takashi Muramatsu

Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
884 KB
Volume
74
Category
Article
ISSN
0020-7136

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✦ Synopsis

A 60-kDa glycoprotein named metanestin was identified by molecular cloning. The glycoprotein had a twice-repeated motif of Pro-Gly-Pro-Gly and carried metastasis-associated carbohydrate epitopes. The antibody to the protein portion of metanestin strongly reacted with lymph-node metastasis of transitional-cell carcinoma of the urinary bladder, but the reactivity to the primary tumor was generally weaker and the normal urothelium was scarcely reactive. Thus both metanestin and the carbohydrate on it showed metastasis-associated expression. In addition, we identified a 100-kDa glycoprotein with a 4-times-repeated motif of Pro-Ala-Pro-Ala. The antibody to the 100-kDa glycoprotein showed reactivity similar to that to metanestin.

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## Abstract ## BACKGROUND Patients with transitional cell carcinoma (TCC) of the urinary bladder metastatic to regional lymph nodes (LN) typically have a poor prognosis. However, some patients are cured by radical cystectomy alone. The goal of this study was to identify predictors of survival in t