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Metallation of 1-dialkylaminobenzimidazoles

✍ Scribed by V. V. Kuz'menko; I. A. Filatova; A. F. Pozharskii


Publisher
Springer US
Year
1992
Tongue
English
Weight
498 KB
Volume
28
Category
Article
ISSN
0009-3122

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Regioselective metallation and alkylation/acylation of 2-aryl-1,3-dioxanes was achieved in high yield.

Stereoelectronic effects on metallation
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Metallation of the acetal (H-2) proton in 1,3-dioxolanes, 1,3-dioxanes and open chain acetals is possible only if the proton can occupy an "equatorial-like" conformation.