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Metalation of t-butyl sulfoxides, sulfones and sulfonamides of pyridazine and pyrazine. Metalation of diazines. XX

✍ Scribed by Alain Turck; Nelly Plé; Paméla Pollet; Guy Quéguiner

Book ID
102892848
Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
628 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

In the pyridazine series, the use of tert‐butylsulfinyl and tert‐butylsulfonyl as ortho directing groups for metalation has been tested. Various functionalized products were obtained in good yields. In the case of 3‐tert‐butylsulfinyl‐6‐methoxypyridazine, the metalation was regioselective in ortho to the sulfinyl group. The metalation of 2‐tert‐butylsulfinyl and 2‐tert‐butylsulfonylpyrazine gave low to moderate yields. Synthesis of diazinesulfonamides were improved and the metalation of N‐tert‐butylsulfonamidopyrazine was achieved.

📜 SIMILAR VOLUMES

ChemInform Abstract: Advances in the Dir
ChemInform Abstract: Advances in the Directed Metalation of Azines and Diazines (Pyridines, Pyrimidines, Pyrazines, Pyridazines, Quinolines, Benzodiazines, and Carbolines). Part 2. Metalation of Pyrimidines, Pyrazines, Pyridazines, and Benzodiazines.
✍ Alain Turck; Nelly Ple; Florence Mongin; Guy Queguiner 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB 👁 2 views

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