Metal oxide in aqueous organic solution promoted chemoselective N-sulfonylation of hydrophilic amino alcohols

✍ Scribed by Hak Hee Kang; Ho Sik Rho; Duck Hee Kim; Seong-Geun Oh

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 128 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01666-6

✦ Synopsis

The reaction of hydrophilic amino alcohols with sulfonyl chlorides in the presence of metal oxide (MgO, CuO, Ag 2 O) in aqueous organic solution cleanly provided alkanolsulfonamide. Advantages of this method were mild, neutral reaction conditions, chemoselectivity and easy isolation of the final product.