Chemoselective N-acylation of amino alcohols promoted by magnesium oxide in aqueous organic solution
✍ Scribed by Duck-Hee Kim; Ho-Sik Rho; Jae Won You; Jong Chan Lee
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 54 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The reaction of hydrophilic amino alcohols with acid chlorides in the presence of magnesium oxide in aqueous organic solution (THF/H 2 O=4:1) cleanly provided alkanolamides.
📜 SIMILAR VOLUMES
The reaction of hydrophilic amino alcohols with sulfonyl chlorides in the presence of metal oxide (MgO, CuO, Ag 2 O) in aqueous organic solution cleanly provided alkanolsulfonamide. Advantages of this method were mild, neutral reaction conditions, chemoselectivity and easy isolation of the final pro
## Abstract The kinetics and mechanism of the silver(II) oxidation of methanol, ethanol, 1‐propanol, 1‐methyl‐ ethanol, 1‐butanol, 2‐methyl‐1‐propanol, 2‐butanol, 2‐methyl‐2‐propanol, D~4~‐methanol, and D~6~‐methanol have been investigated at 8.0 and 20.0°C in aqueous perchloric acid media (1.00 ≤